The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

Specificity of eukaryotic protein degradation is determined by E3 ubiquitin ligases and their
selective binding to protein motifs, termed" degrons," in substrates for ubiquitin-mediated …

The N-end rule pathway is a proteolytic system in which N-terminal residues of short-lived
proteins are recognized by recognition components (N-recognins) as essential components …

Protein degradation plays a central role in many cellular functions. Misfolded and damaged
proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins …

Members of the AAA+ protein superfamily contribute to many diverse aspects of protein
homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic …

The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue
and its post-translational modification. Since its discovery 25 years ago, the pathway …

UBR box E3 ligases, also called N-recognins, are integral components of the N-degron
pathway. Representative N-recognins include UBR1, UBR2, UBR4, and UBR5, and they …

Most bacteria live in a dynamic environment where temperature, availability of nutrients and
the presence of various chemicals vary, which requires rapid adaptation. Many of the …

The N-end rule pathway senses the N-terminal destabilizing residues of degradation
substrates for the ubiquitin-proteasome system, whose integrity shields against various …

Plastid protein homeostasis is critical during chloroplast biogenesis and responses to
changes in environmental conditions. Proteases and molecular chaperones involved in …