Due to their ability to shuttle proteins, lipids and genetic material between distant cells,
exosomes promote extensive phenotypic changes in recipient cells, modulating immune …

Neurodegenerative disorders are spreading worldwide and are one of the greatest threats to
public health. There is currently no adequate therapy for these disorders, and therefore there …

The sequence specificity of the endogenous RNA interference pathway allows targeted
suppression of genes essential for insect survival and enables the development of durable …

The recent identification of several novel endocytic compartments has challenged our
current understanding of the topological and functional organization of the endocytic …

Multivesicular bodies (MVBs) are intracellular endosomal organelles characterized by
multiple internal vesicles that are enclosed within a single outer membrane. MVBs were …

Mutations in CHMP2B cause frontotemporal dementia (FTD) in a large Danish pedigree,
which is termed FTD linked to chromosome 3 (FTD-3), and also in an unrelated familial FTD …

TMEM106B was identified as a major risk factor in a genome-wide association study for
frontotemporal lobar degeneration (FTLD) with TAR DNA-binding protein (TDP)-43 …

Cardiomyocyte proteostasis is mediated by the ubiquitin/proteasome system (UPS) and
autophagy/lysosome system and is fundamental for cardiac adaptation to both physiologic …

Autophagy is an intracellular degradation process responsible for the clearance of most long-
lived proteins and organelles. Cytoplasmic components are enclosed by double-membrane …

Neurons have highly dynamic cellular processes for their proper functions such as cell
growth, synaptic formation, or synaptic plasticity by regulating protein synthesis and …