The blood–brain barrier (BBB) plays a vital role in the protection and maintenance of
homeostasis in the brain. In this way, it is an interesting target as an interface for various …

Introduction: The failure of many molecules as CNS bioactive compounds is due to many
restrictions: poor water solubility, intestinal absorption, in vivo stability, bioavailability …

Vitamin B12 (cyanocobalamin) deficiency is a widespread condition because of its different
aetiologies, like malabsorption syndrome or lifestyles as strict veganism that is increasing its …

Nanoparticles are ubiquitous in the environment and are widely used in medical science (eg
bioimaging, diagnosis, and drug therapy delivery). Due to unique physicochemical …

Background Multi-target drugs have gained significant recognition for the treatment of
multifactorial diseases such as depression. Under a screening study of multi-potent …

Purpose Mesoporous silica nanoparticles (MSNPs) are excellent candidates for biomedical
applications and drug delivery to different human body areas, the brain included. Although …

We previously showed the ability of liposomes bi-functionalized with phosphatidic acid and
an ApoE-derived peptide (mApoE-PA-LIP) to reduce brain Aβ in transgenic Alzheimer mice …

Cardiolipin, an anionic phospholipid found primarily in the inner mitochondrial membrane,
has many well-defined roles within the peripheral tissues, including the maintenance of …

A small library of degradable polyester-like glycopolymers was successfully prepared by the
combination of radical ring-opening copolymerization of 2-methylene-1, 3-dioxepane as a …

Aim: We report the physicochemical analysis of nanosystems intended for cardiovascular
applications and their toxicological characterization in static and dynamic cell culture …