Nanobodies can be seen as next‐generation tools for the recognition and modulation of
antigens that are inaccessible to conventional antibodies. Due to their compact structure and …

Site‐selective protein functionalization serves as an invaluable tool for investigating protein
structures and functions in complicated cellular environments and accomplishing semi …

Microbial transglutaminase (MTG) was stably solid‐phase immobilized on glass microbeads
by using a second‐generation dendronized polymer. Immobilized MTG enabled the efficient …

Fluorescence microscopy imaging enables receptor proteins to be investigated within their
biological context. A key challenge is to site‐specifically incorporate reporter moieties into …

Formylglycine‐generating enzymes are of increasing interest in the field of bioconjugation
chemistry. They catalyze the site‐specific oxidation of a cysteine residue to the aldehyde …

Antibody‐drug conjugates (ADCs) are multicomponent biomolecules that have emerged as
a powerful tool for targeted tumor therapy. Combining specific binding of an immunoglobulin …

We describe the synthesis and application of a selection of trifunctional reagents for the dual‐
modality modification of native, solvent accessible disulfide bonds in trastuzumab. The …

Tubulin detyrosination‐tyrosination cycle regulates the stability of microtubules. With respect
to α‐tubulins, the tyrosination level is maintained by a single tubulin‐tyrosine ligase (TTL) …

In classic bioorthogonal labeling experiments, the cell's biosynthetic machinery incorporates
bioorthogonal tags, creating tagged biomolecules that are subsequently reacted with a …

Nanobodys sind ein modernes Mittel zur Erkennung und Modulation von Antigenen, die für
herkömmliche Antikörper unzugänglich sind. Aufgrund ihrer kompakten Form und ihrer …