In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …

Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …

Progression through fate decisions determines cellular composition and tissue architecture,
but how that same architecture may impact cell fate is less clear. We took advantage of …

The achievement of an HIV cure is dependent on the eradication or permanent silencing of
HIV-latent viral reservoirs, including the understudied central nervous system (CNS) …

The current methods of generating human cerebral organoids rely excessively on the use of
Matrigel or other external extracellular matrices (ECM) for cell micro-environmental …

An organoid is a miniaturized and simplified in vitro model with a similar structure and
function to a real organ. In recent years, the use of organoids has increased explosively in …

Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …

Many neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease,
frontotemporal dementia, amyotrophic lateral sclerosis and Huntington's disease, are …

Background Mitochondrial dysfunction is involved in several diseases ranging from genetic
mitochondrial disorders to chronic metabolic diseases. An emerging approach to potentially …