Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …

Mammalian adipose tissue can be divided into two major types, namely, white adipose
tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function …

Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a
fundamental fuel for oxidative phosphorylation in mitochondria, and preferred over glucose …

Brown adipose tissue (BAT) is well known to burn calories through uncoupled respiration,
producing heat to maintain body temperature. This 'calorie wasting'feature makes BAT a …

Monocarboxylate transporters (MCTs) represent a diverse group of transmembrane proteins
encoded by the SLC16 gene family found ubiquitously across mammalian species. Two …

Our understanding of brown adipose tissue (BAT) function in humans has increased rapidly
over the past 10 years. This is predominantly due to the development of powerful non …

Coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2 infection has
now evolved into a worldwide crisis that triggers substantial morbidity and mortality. COVID …

Objective The gut microbiota regulates thermogenesis to benefit metabolic homeostasis at
least partially via its metabolite butyrate, and the underlying mechanisms of this regulation …

Metabolism consists of life-sustaining chemical reactions involving metabolites. Historically,
metabolites were defined as the intermediates or end products of metabolism and …

The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult
humans have offered a new approach to treating obesity and metabolic diseases. Beyond …