Integration of proteomics in the molecular tumor board

J Thiery, M Fahrner - Proteomics, 2024 - Wiley Online Library
Cancer remains one of the most complex and challenging diseases in mankind. To address
the need for a personalized treatment approach for particularly complex tumor cases …

[HTML][HTML] Mass Spectrometry Advancements and Applications for Biomarker Discovery, Diagnostic Innovations, and Personalized Medicine

A Son, W Kim, J Park, Y Park, W Lee, S Lee… - International Journal of …, 2024 - mdpi.com
Mass spectrometry (MS) has revolutionized clinical chemistry, offering unparalleled
capabilities for biomolecule analysis. This review explores the growing significance of mass …

Assessment of a 60-biomarker health surveillance panel (HSP) on whole blood from remote sampling devices by targeted LC/MRM-MS and discovery DIA-MS …

SA Whelan, N Hendricks, ZL Dwight, Q Fu… - Analytical …, 2023 - ACS Publications
Telehealth, accessing healthcare and wellness remotely, should be a cost-effective and
efficient way for individuals to receive care. The convenience of having a reliable remote …

Validation and quantification of peptide antigens presented on MHCs using SureQuant

O Leddy, Y Cui, R Ahn, L Stopfer, E Choe, DH Kim… - Nature …, 2024 - nature.com
Vaccines and immunotherapies that target peptide–major histocompatibility complexes
(peptide–MHCs) have the potential to address multiple unmet medical needs in cancer and …

[HTML][HTML] Multi-omic stratification of the missense variant cysteinome

H Desai, S Ofori, L Boatner, F Yu, M Villanueva, N Ung… - BioRxiv, 2023 - ncbi.nlm.nih.gov
Cancer genomes are rife with genetic variants; one key outcome of this variation is gain-
ofcysteine, which is the most frequently acquired amino acid due to missense variants in …

[HTML][HTML] Biomarker-Based Precision Therapy for Alzheimer's Disease: Multidimensional Evidence Leading a New Breakthrough in Personalized Medicine

A Bougea, P Gourzis - Journal of Clinical Medicine, 2024 - mdpi.com
(1) Background: Alzheimer's disease (AD) is a worldwide neurodegenerative disorder
characterized by the buildup of abnormal proteins in the central nervous system and …

Tumor-intrinsic kinome landscape of pancreatic cancer reveals new therapeutic approaches

Y Xu, XL Peng, MP East, IC McCabe… - Cancer …, 2025 - aacrjournals.org
Effective therapies for pancreatic ductal adenocarcinoma (PDAC) have been largely elusive.
In this study, we perform multiplexed kinase inhibitor bead mass spectrometry on 102 patient …

Realm of proteomics in breast cancer management and drug repurposing to alleviate intricacies of treatment

RN Behera, VS Bisht, K Giri… - PROTEOMICS–Clinical …, 2023 - Wiley Online Library
Breast cancer, a multi‐networking heterogeneous disease, has emerged as a serious
impediment to progress in clinical oncology. Although technological advancements and …

Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy

LA Beer, X Yin, J Ding, S Senapati, MD Sammel… - Clinical Proteomics, 2023 - Springer
Background Differentiating between a normal intrauterine pregnancy (IUP) and abnormal
conditions including early pregnancy loss (EPL) or ectopic pregnancy (EP) is a major clinical …

[HTML][HTML] Foresight in clinical proteomics: current status, ethical considerations, and future perspectives

F Mundt, NJW Albrechtsen, SP Mann, P Treit… - Open Research …, 2023 - ncbi.nlm.nih.gov
With the advent of robust and high-throughput mass spectrometric technologies and
bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic …