Large-scale neural recordings call for new insights to link brain and behavior

AE Urai, B Doiron, AM Leifer, AK Churchland - Nature neuroscience, 2022 - nature.com
Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …

Imaging whole-brain activity to understand behaviour

A Lin, D Witvliet, L Hernandez-Nunez… - Nature Reviews …, 2022 - nature.com
Until now, most brain studies have focused on small numbers of neurons that interact in
limited circuits, allowing analysis of individual computations or steps of neural processing …

[HTML][HTML] Neural signal propagation atlas of Caenorhabditis elegans

F Randi, AK Sharma, S Dvali, AM Leifer - Nature, 2023 - nature.com
Establishing how neural function emerges from network properties is a fundamental problem
in neuroscience. Here, to better understand the relationship between the structure and the …

[HTML][HTML] Molecular topography of an entire nervous system

SR Taylor, G Santpere, A Weinreb, A Barrett, MB Reilly… - Cell, 2021 - cell.com
We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …

[HTML][HTML] Network statistics of the whole-brain connectome of Drosophila

A Lin, R Yang, S Dorkenwald, A Matsliah, AR Sterling… - Nature, 2024 - nature.com
Brains comprise complex networks of neurons and connections, similar to the nodes and
edges of artificial networks. Network analysis applied to the wiring diagrams of brains can …

The neuropeptidergic connectome of C. elegans

L Ripoll-Sánchez, J Watteyne, HS Sun, R Fernandez… - Neuron, 2023 - cell.com
Efforts are ongoing to map synaptic wiring diagrams, or connectomes, to understand the
neural basis of brain function. However, chemical synapses represent only one type of …

Unique homeobox codes delineate all the neuron classes of C. elegans

MB Reilly, C Cros, E Varol, E Yemini, O Hobert - Nature, 2020 - nature.com
It is not known at present whether neuronal cell-type diversity—defined by cell-type-specific
anatomical, biophysical, functional and molecular signatures—can be reduced to relatively …

Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin

NY Tsai, F Wang, K Toma, C Yin, J Takatoh… - Nature …, 2022 - nature.com
The mouse visual system serves as an accessible model to understand mammalian circuit
wiring. Despite rich knowledge in retinal circuits, the long-range connectivity map from …

Brain-wide representations of behavior spanning multiple timescales and states in C. elegans

AA Atanas, J Kim, Z Wang, E Bueno, MC Becker… - Cell, 2023 - cell.com
Changes in an animal's behavior and internal state are accompanied by widespread
changes in activity across its brain. However, how neurons across the brain encode …

Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale

U Dag, I Nwabudike, D Kang, MA Gomes, J Kim… - Cell, 2023 - cell.com
Serotonin influences many aspects of animal behavior. But how serotonin acts on its diverse
receptors across the brain to modulate global activity and behavior is unknown. Here, we …