An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the
pharmaceutical sciences. We summarize successful fragment-to-lead studies that were …

Pseudomonas aeruginosa is a major cause of nosocomial infections and also leads to
severe exacerbations in cystic fibrosis or chronic obstructive pulmonary disease. Three …

The emergence and the dissemination of multidrug-resistant bacteria constitute a major
public health issue. Among incriminated Gram-negative bacteria, Pseudomonas aeruginosa …

Fragment-based drug discovery (FBDD) has grown and matured to a point where it is
valuable to keep track of its extent and details of application. This Perspective summarizes …

Resistance to antibiotics is a critical growing public health problem that desires urgent action
to combat. To avoid the stress on bacterial growth that evokes the resistance development …

Rising numbers of cases of multidrug-and extensively drug-resistant Pseudomonas
aeruginosa over recent years have created an urgent need for novel therapeutic …

Pseudomonas aeruginosa (PA) is an opportunistic human pathogen, which is involved in a
wide range of dangerous infections. It develops alarming resistances toward antibiotic …

LysR-type transcriptional regulators (LTTRs) form one of the largest families of bacterial
regulators. They are widely distributed and contribute to all aspects of metabolism and …

Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium responsible for
acute and chronic infections in planktonic state or in biofilms. The sessile structures are …