Roles of nonhomologous DNA end joining, V (D) J recombination, and class switch recombination in chromosomal translocations
MR Lieber, K Yu, SC Raghavan - DNA repair, 2006 - Elsevier
When a single double-strand break arises in the genome, nonhomologous DNA end joining
(NHEJ) is a major pathway for its repair. When double-strand breaks arise at two …
(NHEJ) is a major pathway for its repair. When double-strand breaks arise at two …
The RNA tether model for human chromosomal translocation fragile zones
D Liu, CL Hsieh, MR Lieber - Trends in Biochemical Sciences, 2024 - cell.com
One of the two chromosomal breakage events in recurring translocations in B cell
neoplasms is often due to the recombination-activating gene complex (RAG complex) …
neoplasms is often due to the recombination-activating gene complex (RAG complex) …
The dynamic regulation of G-quadruplex DNA structures by cytosine methylation
AJ Stevens, L de Jong, MA Kennedy - International Journal of Molecular …, 2022 - mdpi.com
It is well known that certain non B-DNA structures, including G-quadruplexes, are key
elements that can regulate gene expression. Here, we explore the theory that DNA …
elements that can regulate gene expression. Here, we explore the theory that DNA …
Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t (14; 18) translocation
The most common chromosomal translocation in cancer, t (14; 18), occurs at the bcl-2 major
breakpoint region (Mbr) in follicular lymphomas. The 150-bp bcl-2 Mbr, which contains three …
breakpoint region (Mbr) in follicular lymphomas. The 150-bp bcl-2 Mbr, which contains three …
Delineating the mechanism of fragility at BCL6 breakpoint region associated with translocations in diffuse large B cell lymphoma
V Gopalakrishnan, U Roy, S Srivastava… - Cellular and Molecular …, 2024 - Springer
BCL6 translocation is one of the most common chromosomal translocations in cancer and
results in its enhanced expression in germinal center B cells. It involves the fusion of BCL6 …
results in its enhanced expression in germinal center B cells. It involves the fusion of BCL6 …
Identification and characterization of mercaptopyrimidine‐based small molecules as inhibitors of nonhomologous DNA end joining
Mercaptopyrimidine derivatives are heterocyclic compounds with potent biological activities
including antiproliferative, antibacterial, and anti‐inflammatory properties. The present study …
including antiproliferative, antibacterial, and anti‐inflammatory properties. The present study …
[PDF][PDF] Triplex DNA and human disease
JJ Bissler - Front Biosci, 2007 - article.imrpress.com
Introduction 3. Polypurine· polypyrimidine mirror repeat tracts and triplex 4. Types of Triplex
DNA Structures 5. Identification of Triplex DNA 5.1. Two-dimensional gel electrophoresis …
DNA Structures 5. Identification of Triplex DNA 5.1. Two-dimensional gel electrophoresis …
Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro
SC Raghavan, PC Swanson, Y Ma… - Molecular and cellular …, 2005 - Taylor & Francis
The most common chromosomal translocation in cancer, t (14; 18) at the 150-bp bcl-2 major
breakpoint region (Mbr), occurs in follicular lymphomas. The bcl-2 Mbr assumes a non-B …
breakpoint region (Mbr), occurs in follicular lymphomas. The bcl-2 Mbr assumes a non-B …
Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t (8; 14) translocations in sporadic Burkitt …
K Busch, T Keller, U Fuchs, RF Yeh, J Harbott, I Klose… - Leukemia, 2007 - nature.com
Abstract The chromosomal translocation t (8; 14) is the hallmark of Burkitt's-lymphoma (BL)
and fuses the proto-oncogene c-MYC to the IGH locus. We analyzed the genomic structure …
and fuses the proto-oncogene c-MYC to the IGH locus. We analyzed the genomic structure …
DNA structures at chromosomal translocation sites
SC Raghavan, MR Lieber - Bioessays, 2006 - Wiley Online Library
It has been unclear why certain defined DNA regions are consistently sites of chromosomal
translocations. Some of these are simply sequences of recognition by endogenous …
translocations. Some of these are simply sequences of recognition by endogenous …