From Stem Cells to Populations—Using hiPSC, Next-Generation Sequencing, and GWAS to Explore the Genetic and Molecular Mechanisms of Congenital Heart …
M Broberg, J Hästbacka, E Helle - Genes, 2021 - mdpi.com
Congenital heart defects (CHD) are developmental malformations affecting the heart and the
great vessels. Early heart development requires temporally regulated crosstalk between …
great vessels. Early heart development requires temporally regulated crosstalk between …
Genetic determinants of the interventricular septum are linked to ventricular septal defects and hypertrophic cardiomyopathy
Background: A large proportion of genetic risk remains unexplained for structural heart
disease involving the interventricular septum (IVS) including hypertrophic cardiomyopathy …
disease involving the interventricular septum (IVS) including hypertrophic cardiomyopathy …
Considering the Genetic Architecture of Hypoplastic Left Heart Syndrome
JW Belmont - Journal of Cardiovascular Development and Disease, 2022 - mdpi.com
Hypoplastic left heart syndrome (HLHS) is among the most severe cardiovascular
malformations and understanding its causes is crucial to making progress in prevention and …
malformations and understanding its causes is crucial to making progress in prevention and …
Genetics and etiology of congenital heart disease.
Congenital heart disease (CHD) is the most common severe birth anomaly, affecting almost
1% of infants. Most CHD is genetic, but only 40% of patients have an identifiable genetic risk …
1% of infants. Most CHD is genetic, but only 40% of patients have an identifiable genetic risk …
Genetic determinants of interventricular septal anatomy and the risk of ventricular septal defects and hypertrophic cardiomyopathy
Background The interventricular septum (IVS) plays a primary role in cardiovascular
physiology and a large proportion of genetic risk remains unexplained for structural heart …
physiology and a large proportion of genetic risk remains unexplained for structural heart …