Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to
be the most significant problem in the field of cancer. Patients who present with metastatic …

The dog has emerged as a premier species for the study of morphology, behavior, and
disease. The recent availability of a high-quality draft sequence lifts the dog system to a new …

Dogs with osteosarcoma provide an important model for the same disease in humans. In this
report, the comparative nature of human and canine osteosarcoma including incidence and …

Extensive genetic resources and a high-quality genome sequence position the dog as an
important model species for understanding genome evolution, population genetics and …

Abstract In 2003, the US National Human Genome Research Institute (NHGRI) agreed to
fund a project to sequence the entire genome of a boxer dog named Tasha. Although the …

The domestication of the dog from its wolf ancestors is perhaps the most complex genetic
experiment in history, and certainly the most extensive. Beginning with the wolf, man has …

With many caveats to the traditional vertebrate species pertaining to biogerontology
investigations, it has been suggested that a most informative model is the one which: 1) …

There is limited information describing species related pharmacogenetic differences in
animals. Despite the lack of genetic information in veterinary medicine, breed specific …

The issue of inherited disorders in pedigree dogs is not a recent phenomenon and reports of
suspected genetic defects associated with breeding practices date back to Charles Darwin's …

Dogs have become a valuable model in exploring multifaceted diseases and biology
relevant to human health. Despite large-scale dog genome projects producing high-quality …