Conspectus One of the fundamental goals of chemists is to develop highly efficient methods
for producing optically active compounds, given their wide range of applications in …

Enzymes are the core for biological transformations in nature. Their structures and functions
have drawn enormous attention from biologists as well as chemists since last century. The …

Functionalization of inert C–H bonds has received tremendous attention due to the inherent
atom economy and efficiency of the transformations of the starting materials. As compared to …

The upregulation of 4-hydroxyphenylpyruvate dioxygenase (HPPD) can protect plants from
adverse abiotic stress. Therefore, studying the changes of HPPD under abiotic stress is …

The Strecker reaction of aldehydes is the pre-eminent pathway to explain the prebiotic
origins of α-amino acids. However, biology employs transamination of α-ketoacids to …

Owing to the strong nucleophilicity of the NH2 group, free‐NH2 glycinates react with MBH
acetates to usually deliver N‐allylated products even in the absence of catalysts. Without …

Direct asymmetric functionalization of the inert α C− H bonds of N‐unprotected propargylic
amines is a big challenge in organic chemistry, due to the low acidity (pKa≈ 42.6) of the α …

An unprecedented tandem carbonylation/aminocarbonylation triggered by palladium-
catalyzed enantioselective Heck-type exocyclopalladation delivering chiral heterocyclic α …

An unprecedented highly enantioselective Ru‐catalyzed direct asymmetric reductive
amination of α‐keto amides with ammonium salts has been disclosed, efficiently offering …

Many enzymes work in tandem with small molecule cofactors, which have inspired
organocatalyst designs. Chemical modification of cofactor scaffolds has increased …