This review highlights the multifunctional properties of perlecan (HSPG2) and its potential
roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose …

The extracellular matrix proteoglycan (ECM) perlecan, also known as heparan sulfate
proteoglycan 2 or HSPG2, is one of the largest (> 200 nm) and oldest (> 550 M years) …

Stroke is the second leading cause of death worldwide and has two major subtypes:
ischemic stroke and hemorrhagic stroke. Neuroinflammation is a pathological hallmark of …

Proteoglycans have emerged as biomacromolecules with important roles in matrix
remodeling, homeostasis, and signaling in the past two decades. Due to their negatively …

Therapeutic angiogenesis has long been considered a viable treatment for vasculature
disruptions, including cerebral vasculature diseases. One widely-discussed treatment …

Ischemicstroke is a leading cause of death and disability in the United States, but recent
advances in treatments [ie, endovascular thrombectomy and tissue plasminogen activator (t …

Stroke is one of the leading causes of mortality and morbidity worldwide. The bloodbrain
barrier (BBB) is a characteristic structure of microvessel within the brain. Under normal …

Ischemic stroke causes blood–brain barrier (BBB) breakdown due to significant damage to
the integrity of BBB components. Recent studies have highlighted the importance of …

Endothelial cells acquire different phenotypes to establish functional vascular networks.
Vascular endothelial growth factor (VEGF) signaling induces endothelial proliferation …

Background Stroke remains a leading cause of death and disability worldwide despite
recent treatment breakthroughs. A primary event in stroke pathogenesis is the development …