[HTML][HTML] Fiber-type shifting in sarcopenia of old age: proteomic profiling of the contractile apparatus of skeletal muscles

P Dowling, S Gargan, D Swandulla… - International Journal of …, 2023 - mdpi.com
The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

S Rong, L Wang, Z Peng, Y Liao, D Li… - Journal of cachexia …, 2020 - Wiley Online Library
The age‐related loss of muscle mass and muscle function known as sarcopenia is a primary
contributor to the problems faced by the old people. Sarcopenia has been a major public …

Supplementing glycine and N-acetylcysteine (GlyNAC) in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation …

P Kumar, C Liu, J Suliburk, JW Hsu… - The Journals of …, 2023 - academic.oup.com
Abstract Background Elevated oxidative stress (OxS), mitochondrial dysfunction, and
hallmarks of aging are identified as key contributors to aging, but improving/reversing these …

Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics

C Cherry, DR Maestas, J Han, JI Andorko… - Nature biomedical …, 2021 - nature.com
The understanding of the foreign-body responses to implanted biomaterials would benefit
from the reconstruction of intracellular and intercellular signalling networks in the …

[HTML][HTML] Biogenesis and function of extracellular vesicles in pathophysiological processes of skeletal muscle atrophy

W Wang, M Li, Z Chen, L Xu, M Chang, K Wang… - Biochemical …, 2022 - Elsevier
Pathophysiological changes of skeletal muscle occur in a variety of chronic diseases,
leading to muscle atrophy and dysfunction, which greatly affect the quality of life. Despite …

[HTML][HTML] State of knowledge on molecular adaptations to exercise in humans: historical perspectives and future directions

KM Lavin, PM Coen, LC Baptista, MB Bell… - Comprehensive …, 2022 - ncbi.nlm.nih.gov
For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …

Circulating exosome‐like vesicle and skeletal muscle microRNAs are altered with age and resistance training

D Xhuti, MI Nilsson, K Manta… - The Journal of …, 2023 - Wiley Online Library
The age‐related loss of skeletal muscle mass and functionality, known as sarcopenia, is a
critical risk factor for morbidity and all‐cause mortality. Resistance exercise training (RET) is …

[HTML][HTML] Dual role of reactive oxygen species in muscle function: can antioxidant dietary supplements counteract age-related sarcopenia?

S Damiano, E Muscariello, G La Rosa… - International journal of …, 2019 - mdpi.com
Sarcopenia is characterized by the progressive loss of skeletal muscle mass and strength. In
older people, malnutrition and physical inactivity are often associated with sarcopenia, and …

A neuromuscular perspective of sarcopenia pathogenesis: Deciphering the signaling pathways involved

A Moreira-Pais, R Ferreira, PA Oliveira, JA Duarte - Geroscience, 2022 - Springer
The escalation of life expectancy is accompanied by an increase in the prevalence of age-
related conditions, such as sarcopenia. Sarcopenia, a muscle condition defined by low …

Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis

KA Britson, JP Ling, KE Braunstein… - Science translational …, 2022 - science.org
Sporadic inclusion body myositis (IBM) is the most common acquired muscle disease in
adults over age 50, yet it remains unclear whether the disease is primarily driven by T cell …