Regulation of SIRT1 and its roles in inflammation
Y Yang, Y Liu, Y Wang, Y Chao, J Zhang, Y Jia… - Frontiers in …, 2022 - frontiersin.org
The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …
[PDF][PDF] Satellite cells and skeletal muscle regeneration
Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are
susceptible to senescence during aging. We demonstrate the importance of the amount of …
susceptible to senescence during aging. We demonstrate the importance of the amount of …
The NAD+-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells
Stem cells undergo a shift in metabolic substrate utilization during specification and/or
differentiation, a process that has been termed metabolic reprogramming. Here, we report …
differentiation, a process that has been termed metabolic reprogramming. Here, we report …
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism
R Nogueiras, KM Habegger… - Physiological …, 2012 - journals.physiology.org
The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …
cellular sensors to detect energy availability and modulate metabolic processes. Two …
Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling
The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …
The role of sirtuins in cardiac disease
S Matsushima, J Sadoshima - American Journal of …, 2015 - journals.physiology.org
Modification of histones is one of the important mechanisms of epigenetics, in which genetic
control is determined by factors other than an individual's DNA sequence. Sirtuin family …
control is determined by factors other than an individual's DNA sequence. Sirtuin family …
Retinoic acid receptors: from molecular mechanisms to cancer therapy
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
The different shades of fat
V Peirce, S Carobbio, A Vidal-Puig - Nature, 2014 - nature.com
Our understanding of adipose tissue biology has progressed rapidly since the turn of the
century. White adipose tissue has emerged as a key determinant of healthy metabolism and …
century. White adipose tissue has emerged as a key determinant of healthy metabolism and …
[HTML][HTML] Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
M Lagouge, C Argmann, Z Gerhart-Hines, H Meziane… - Cell, 2006 - cell.com
Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated
with reduced longevity. We tested whether resveratrol (RSV), which is known to extend …
with reduced longevity. We tested whether resveratrol (RSV), which is known to extend …