Sex differences in immunity to viral infections

H Jacobsen, SL Klein - Frontiers in immunology, 2021 - frontiersin.org
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences
in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias …

Estrogen receptor signaling in the immune system

B Chakraborty, J Byemerwa, T Krebs, F Lim… - Endocrine …, 2023 - academic.oup.com
The immune system functions in a sexually dimorphic manner, with females exhibiting more
robust immune responses than males. However, how female sex hormones affect immune …

Factors associated with post-acute sequelae of SARS-CoV-2 (PASC) after diagnosis of symptomatic COVID-19 in the inpatient and outpatient setting in a diverse …

SM Yoo, TC Liu, Y Motwani, MS Sim… - Journal of general …, 2022 - Springer
Background The incidence of persistent clinical symptoms and risk factors in Post-Acute
Sequelae of SARS-CoV-2 (PASC) in diverse US cohorts is unclear. While there are a …

Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society

JE Roeters van Lennep, LS Tokgözoğlu… - European heart …, 2023 - academic.oup.com
Cardiovascular disease is the leading cause of death in women and men globally, with most
due to atherosclerotic cardiovascular disease (ASCVD). Despite progress during the last 30 …

[HTML][HTML] Xist ribonucleoproteins promote female sex-biased autoimmunity

DR Dou, Y Zhao, JA Belk, Y Zhao, KM Casey, DC Chen… - Cell, 2024 - cell.com
Autoimmune diseases disproportionately affect females more than males. The XX sex
chromosome complement is strongly associated with susceptibility to autoimmunity. Xist …

Suppressive effects of androgens on the immune system

A Trigunaite, J Dimo, TN Jørgensen - Cellular immunology, 2015 - Elsevier
Sex-based disparities in immune responses are well known phenomena. The two most
important factors accounting for the sex-bias in immunity are genetics and sex hormones …

Systematic review and meta-analysis of sex-specific COVID-19 clinical outcomes

T Galbadage, BM Peterson, J Awada, AS Buck… - Frontiers in …, 2020 - frontiersin.org
To successfully mitigate the extraordinary devastation caused by the Coronavirus disease
2019 (COVID-19) pandemic, it is crucial to identify important risk factors for this disease. One …

[HTML][HTML] Atherosclerotic cardiovascular disease risk assessment: An American Society for Preventive Cardiology clinical practice statement

ND Wong, MJ Budoff, K Ferdinand, IM Graham… - American journal of …, 2022 - Elsevier
Risk for atherosclerotic cardiovascular disease (ASCVD) shows considerable heterogeneity
both in generally healthy persons and in those with known ASCVD. The foundation of …

Cumulative childhood stress and autoimmune diseases in adults

SR Dube, DL Fairweather, WS Pearson… - Psychosomatic …, 2009 - journals.lww.com
Objective: To examine whether childhood traumatic stress increased the risk of developing
autoimmune diseases as an adult. Methods: Retrospective cohort study of 15,357 adult …

The autoimmune basis of alopecia areata: a comprehensive review

N Islam, PSC Leung, AC Huntley, ME Gershwin - Autoimmunity reviews, 2015 - Elsevier
Alopecia areata (AA) is a common, non-scarring dermatologic condition regularly
distinguished by patches of hair loss on the scalp also manifesting in other, severe forms …