It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Pulmonary arterial hypertension (PAH) remains a mysterious killer that, like cancer, is
characterized by tremendous complexity. PAH development occurs under sustained and …

Neutrophil transmigration through venular walls that are composed of endothelial cells
(ECs), pericytes, and the venular basement membrane is a key component of innate …

Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling …

▪ Abstract O2 sensing is a fundamental biological process necessary for adaptation of living
organisms to variable habitats and physiological situations. Cellular responses to hypoxia …

Background—Chronic hypoxic pulmonary hypertension (CH-PHT) is associated with
suppressed expression and function of voltage-gated K+ channels (Kv) in pulmonary artery …

Hypoxia initiates pulmonary vasoconstriction (HPV) by inhibiting one or more voltage-gated
potassium channels (Kv) in the pulmonary artery smooth muscle cells (PASMCs) of …

Chronic hypoxic pulmonary hypertension is associated with profound vascular remodeling
and alterations in Ca2+ homeostasis in pulmonary arterial smooth muscle cells (PASMCs) …

Pulmonary arterial hypertension (PAH) is a severe and progressive disease that usually
culminates in right heart failure and death if left untreated. Although there have been …

Cell apoptosis and proliferation are two counterparts in sharing the responsibility for
maintaining normal tissue homeostasis. In recent years, the process of the programmed cell …