Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

The cancer stem cell (CSC) concept emerged from the recognition of inherent tumor
heterogeneity and suggests that within a given tumor, in analogy to normal tissues, there …

Background Epidermal growth factor receptor (EGFR) is an essential target for cancer
treatment. However, EGFR inhibitor erlotinib showed limited clinical benefit in pancreatic …

The epithelial lining of the intestine, particularly the stem cell compartment, is affected by
harsh conditions in the luminal environment and also is susceptible to genotoxic agents …

Intestinal epithelial self-renewal is a tightly controlled process, which is critically dependent
on WNT signalling. Aberrant activation of the WNT pathway in intestinal stem cells (ISCs) …

In 2023, colorectal cancer (CRC) is the third most diagnosed malignancy and the third
leading cause of cancer death worldwide. At the time of the initial visit, 20% of patients …

Effective treatment regimens for triple-negative breast cancer (TNBC) are relatively scarce
due to a lack of specific therapeutic targets. Epidermal growth factor receptor (EGFR) …

As a pivotal vesicular trafficking protein, Myoferlin (MYOF) has become an attractive target
for cancer therapy. However, the roles of MYOF in colorectal cancer invasion remain …

Introduction Chemoresistance is a major barrier in the treatment of colorectal cancer (CRC)
and many other cancers. ENO1 has been associated with various biological characteristics …

Accumulating evidence indicates that hepatocellular carcinoma (HCC) tumorigenesis,
recurrence, metastasis, and therapeutic resistance are strongly associated with liver cancer …