Organisms experience a wide range of environmental factors such as temperature, salinity
and hydrostatic pressure, which pose challenges to biochemical processes. Studies on …

This study reviews the addition of compatible solutes to biological systems as a strategy to
counteract osmolarity and other environmental stresses. At high osmolarity many …

Life on Earth occupies a multidimensional niche space that has yet to be fully described. The
niche space of terrestrial life is knowable, and thus, it guides the search for hypothesized life …

BACKGROUND: Protein aggregation in the brain is a central hallmark in many
neurodegenerative diseases. In Parkinson's disease, α-synuclein (α-Syn) is the major …

Thermophiles are extremophiles that grow optimally at temperatures> 45° C. To survive and
maintain function of their biological molecules, they have a suite of characteristics not found …

Protein misfolding, aggregation and deposition in the brain, in the form of amyloid, are
implicated in the etiology of several neurodegenerative disorders, such as Alzheimer's …

The application of thermoacidophiles for chalcopyrite (CuFeS 2) bioleaching in hot, acidic,
saline solution was investigated as a possible process route for rapid Cu extraction. The …

Marine hyperthermophiles accumulate small organic compounds, known as compatible
solutes, in response to supraoptimal temperatures or salinities. Pyrococcus furiosus is a …

Halophilic and halotolerant microorganisms adapted to thrive in hot environments
accumulate compatible solutes that usually have a negative charge either associated with a …

The synthesis of di‐myo‐inositol phosphate (DIP), a common compatible solute in
hyperthermophiles, involves the consecutive actions of inositol‐1‐phosphate …