Space radiation biology for “Living in Space”

S Furukawa, A Nagamatsu, M Nenoi… - BioMed Research …, 2020 - Wiley Online Library
Space travel has advanced significantly over the last six decades with astronauts spending
up to 6 months at the International Space Station. Nonetheless, the living environment while …

Interplay of space radiation and microgravity in DNA damage and DNA damage response

M Moreno-Villanueva, M Wong, T Lu, Y Zhang, H Wu - npj Microgravity, 2017 - nature.com
In space, multiple unique environmental factors, particularly microgravity and space
radiation, pose constant threat to the DNA integrity of living organisms. Specifically, space …

Cubesats: Cost-effective science and technology platforms for emerging and developing nations

K Woellert, P Ehrenfreund, AJ Ricco… - Advances in space …, 2011 - Elsevier
The development, operation, and analysis of data from cubesats can promote science
education and spur technology utilization in emerging and developing nations. This platform …

Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravity

C Girardi, C De Pittà, S Casara, G Sales, G Lanfranchi… - PLoS …, 2012 - journals.plos.org
Background Ionizing radiation (IR) can be extremely harmful for human cells since an
improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation …

The efficiency of homologous recombination and non-homologous end joining systems in repairing double-strand breaks during cell cycle progression

L Bee, S Fabris, R Cherubini, M Mognato, L Celotti - PloS one, 2013 - journals.plos.org
This study investigated the efficiency of Non-Homologous End Joining (NHEJ) and
Homologous Recombination (HR) repair systems in rejoining DNA double-strand breaks …

Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation

M Hada, H Ikeda, JR Rhone, AJ Beitman… - International journal of …, 2018 - mdpi.com
Space radiation and microgravity (μ G) are two major environmental stressors for humans in
space travel. One of the fundamental questions in space biology research is whether the …

Cancer studies under space conditions: Finding answers abroad

JL Cortés-Sánchez, J Callant, M Krüger, J Sahana… - Biomedicines, 2021 - mdpi.com
In this review article, we discuss the current state of knowledge in cancer research under
real and simulated microgravity conditions and point out further research directions in this …

Genomic changes driven by radiation-induced DNA damage and microgravity in human cells

A Beheshti, JT McDonald, M Hada… - International Journal of …, 2021 - mdpi.com
The space environment consists of a complex mixture of different types of ionizing radiation
and altered gravity that represents a threat to humans during space missions. In particular …

Effects of simulated microgravity on expression profile of microRNA in human lymphoblastoid cells

LS Mangala, Y Zhang, Z He, K Emami… - Journal of Biological …, 2011 - ASBMB
This study explores the changes in expression of microRNA (miRNA) and related genes
under simulated microgravity conditions. In comparison with static 1× g, microgravity has …

Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks

A Wadhwa, M Moreno-Villanueva, B Crucian, H Wu - Immunity & Ageing, 2024 - Springer
Spaceflight poses a myriad of environmental stressors to astronauts´ physiology including
microgravity and radiation. The individual impacts of microgravity and radiation on the …