[HTML][HTML] Biomedical applications of engineered heparin-based materials

EN Zare, D Khorsandi, A Zarepour, H Yilmaz… - Bioactive Materials, 2024 - Elsevier
Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic
backbone. Due to its fascinating chemical and physical properties, nontoxicity …

Pathophysiological mechanisms of thrombosis in acute and long COVID-19

H Jing, X Wu, M Xiang, L Liu, VA Novakovic… - Frontiers in …, 2022 - frontiersin.org
COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …

Poly (lactic acid)/poly (lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery

F Emami, SJ Mostafavi Yazdi, DH Na - Journal of Pharmaceutical …, 2019 - Springer
Background Pulmonary route is an attractive target for both systemic and local drug delivery,
with the advantages of a large surface area, rich blood supply, and absence of first-pass …

Structure and drug delivery relationship of acidic polysaccharides: a review

R Banerjee, KJ Kumar, JF Kennedy - International Journal of Biological …, 2023 - Elsevier
Scientists from across the world are being inspired by recent development in
polysaccharides and their use in medical administration. Due to their extraordinary physical …

Inhalation of sustained release microparticles for the targeted treatment of respiratory diseases

G Pulivendala, S Bale, C Godugu - Drug delivery and translational …, 2020 - Springer
Delivering drugs through inhalation for systemic and local applications has been in practice
since several decades to treat various diseases. In recent times, inhalation drug delivery is …

A quantitative approach to predicting lung deposition profiles of pharmaceutical powder aerosols

S Yaqoubi, HK Chan, A Nokhodchi… - International Journal of …, 2021 - Elsevier
Dry powder inhalers (DPI) are widely used systems for pulmonary delivery of therapeutics.
The inhalation performance of DPIs is influenced by formulation features, inhaler device and …

Inhaled nano-based therapeutics for inflammatory lung diseases: Recent advances and future prospects

N Gulati, DK Chellappan, R MacLoughlin, K Dua… - Life Sciences, 2021 - Elsevier
Inflammatory lung diseases related morbidity and mortality impose a significant financial
burden. Inflammation is a hallmark of many diseases of the respiratory system which is …

Efficacy and safety of inhaled heparin in asthmatic and chronic obstructive pulmonary disease patients: a systematic review and a meta-analysis

R Ashmawy, A Zaki, A Baess, I El Sayed - Scientific Reports, 2023 - nature.com
Asthma and chronic obstructive pulmonary disease (COPD) are prevalent chronic
respiratory disorders that cause significant morbidity and mortality. Some studies evaluated …

[HTML][HTML] Intratracheal delivery of nano-and microparticles and hyperpolarized gases: a promising strategy for the imaging and treatment of respiratory disease

H Wang, L Wu, X Sun - Chest, 2020 - Elsevier
Accurate diagnosis is crucial to improve the treatment and prognosis of respiratory disease,
especially lung cancer. Tumors and lesions located deep in the lung are directly accessible …

Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway

MA Ghonim, J Wang, SV Ibba, HH Luu… - Journal of Translational …, 2018 - Springer
Background The efficacy of heparins and low-MW-heparins (LMWH) against human asthma
has been known for decades. However, the clinical utility of these compounds has been …