While initial approaches to adoptive T cell therapy relied on the identification and expansion
of rare tumour-reactive T cells, genetic engineering has transformed cancer immunotherapy …

Nearly half of the human genome consists of endogenous retroelements (EREs) and their
genetic remnants, a small fraction of which carry the potential to propagate in the host …

Targeted genome editing (GE) technology has brought a significant revolution in fictional
genomic research and given hope to plant scientists to develop desirable varieties. This …

The prospect of genome editing offers a number of promising opportunities for livestock
breeders. Firstly, these tools can be used in functional genomics to elucidate gene function …

In recent years, immunotherapy for cancer has become mainstream with several products
now authorized for therapeutic use in the clinic and are becoming the standard of care for …

Zinc finger proteins are one of the most abundant families of proteins and present a wide
range of structures and functions. The structural zinc ion provides the correct conformation to …

Genome engineering technologies right from viral vector-mediated to protein-based editing—
which include zinc finger nucleases, TALENs, and CRISPR/Cas systems—have been …

Histidines incorporated into carriers of nucleic acids may enhance the extracellular stability
of the nanoparticle, yet aid in the intracellular disruption of the nanoparticle, enabling the …

Gene editing (GnEd) involves using a site-directed nuclease to introduce a double-strand
break (DSB) at a targeted location in the genome. A literature search was performed on the …

Simple Summary Successful gene therapy mainly depends on the fabrication of efficient and
nontoxic carriers that can compact genetic materials and adequately deliver them to target …