The papillomavirus E2 proteins are pivotal to the viral life cycle and have well characterized
functions in transcriptional regulation, initiation of DNA replication and partitioning the viral …

An important occurrence in cervical carcinogenesis is deregulated expression of the high‐
risk human papillomavirus (HR‐HPV) oncogenes E6 and E7. Several risk factors for cervical …

Cervical cancer cells express high-risk human papillomavirus (HPV) E6 and E7 proteins,
and repression of HPV gene expression causes the cells to cease proliferation and undergo …

Over the last two decades, since the initial discovery of human papillomavirus (HPV) type 16
and 18 DNAs in cervical cancers by Dr. Harald zur Hausen (winner of the Nobel Prize in …

Human papillomaviruses (HPVs) cause squamous cancers of epithelial surfaces, of which
genital cancers are the most common. In this article we have attempted to describe the …

Background Breast cancer is currently the most common neoplasm diagnosed in women
globally. There is a growing body of evidence to suggest that human papillomavirus (HPV) …

Many viruses have as part of their arsenal the ability to modulate the apoptotic pathways of
the host. It is counter-intuitive that such simple organisms would be efficient at regulating this …

Many cancer therapies aim to trigger apoptosis in cancer cells. Nevertheless, the presence
of oncogenic alterations in these cells and distorted composition of tumour …

DNA damage leads to stabilization and accumulation of p53, which plays a pivotal role in
transcriptional activation of p21 and cell cycle arrest. The increase in p53 stability depends …

The human papillomavirus oncoproteins E6 and E7 promote cell proliferation and contribute
to carcinogenesis by interfering with the activities of cellular tumor suppressors. We used a …