Background Chronic and/or extreme stress in early life, often referred to as early adversity,
childhood trauma, or early life stress, has been associated with a wide range of adverse …

It is now widely recognized that children exposed to adverse life events in the first years of
life are at increased risk for a variety of neural, behavioral, and psychological sequelae. As …

Background Childhood maltreatment is the most important preventable cause of
psychopathology accounting for about 45% of the population attributable risk for childhood …

Background: Emotional dysregulation (ED) is a transdiagnostic construct defined as the
inability to regulate the intensity and quality of emotions (such as, fear, anger, sadness), in …

A growing body of research has examined the impact of childhood adversity on neural
structure and function. Advances in our understanding of the neurodevelopmental …

This review examines mechanisms contributing to the intergenerational transmission of self-
regulation. To provide an integrated account of how self-regulation is transmitted across …

Over the past decade, a growing area of research has focused on adverse childhood
experiences (ACEs) and their impacts on neural and developmental outcomes. Work in the …

The immediate and long-term effects of exposure to early life stress (ELS) have been
documented in humans and animal models. Even relatively brief periods of stress during the …

Neurodevelopmental programming—the implementation of the genetic and epigenetic
blueprints that guide and coordinate normal brain development—requires tight regulation of …

Adversity early in life is common and is a major risk factor for the onset of psychopathology.
Delineating the neurodevelopmental pathways by which early adversity affects mental …