Protein synthesis from mRNA is an energy-intensive and tightly controlled cellular process.
Translation elongation is a well-coordinated, multifactorial step in translation that undergoes …

The translation of messenger RNA (mRNA) into proteins represents the culmination of gene
expression. Recent technological advances have revolutionized our ability to investigate this …

Stochasticity has emerged as a mechanism of gene regulation. Much of this so-called"
noise" has been attributed to bursting transcription. Although bursting transcription has been …

The carboxyl-terminal domain of RNA polymerase II (RNAP2) is phosphorylated during
transcription in eukaryotic cells. While residue-specific phosphorylation has been mapped …

Viruses use internal ribosome entry sites (IRES) to hijack host ribosomes and promote cap-
independent translation. Although they are well-studied in bulk, the dynamics of IRES …

A major challenge to our understanding of translational control has been deconvolving the
individual impact specific regulatory factors have on the complex dynamics of mRNA …

Since African swine fever virus (ASFV) replication is closely related to its host's machinery,
codon usage of viral genome can be subject to selection pressures. A better understanding …

Over the past five years, technological advances have made it possible to image the
translation of single mRNA in the natural context of living cells. With these advances …

Understanding how multicellular organisms reliably orchestrate cell-fate decisions is a
central challenge in developmental biology, particularly in early mammalian development …

Computational experiments have been important since the 70s to find solutions to problems
using computers, and even more now with the advancement of technology, especially …