Subtype-dependent regulation of Gβγ signalling
G protein-coupled receptors (GPCRs) transmit information to the cell interior by transducing
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …
[HTML][HTML] Novel splice-site mutation in TTLL5 causes cone dystrophy in a consanguineous family
M de Sousa Dias, CP Hamel, I Meunier, J Varin… - Molecular …, 2017 - ncbi.nlm.nih.gov
Purpose To report the clinical and genetic findings of one family with autosomal recessive
cone dystrophy (CD) and to identify the causative mutation. Methods An institutional study of …
cone dystrophy (CD) and to identify the causative mutation. Methods An institutional study of …
Noncoding variants functional prioritization methods based on predicted regulatory factor binding sites
H Fu, L Yang, X Zhang - Current Genomics, 2017 - ingentaconnect.com
Backgrounds: With the advent of the post genomic era, the research for the genetic
mechanism of the diseases has found to be increasingly depended on the studies of the …
mechanism of the diseases has found to be increasingly depended on the studies of the …
Zebrafish screen of high-confidence targets at insomnia GWAS loci implicates MEIS1, SKIV2L, and ARFGAP2 as conserved regulators of sleep-wake behaviors
AJ Zimmerman, F Doldur-Balli, BT Keenan, ZY Shetty… - bioRxiv, 2022 - biorxiv.org
Study objectives Insomnia is a pervasive sleep disorder with heritability estimates ranging
from 22-59 percent. Human genome-wide association studies (GWAS) have identified more …
from 22-59 percent. Human genome-wide association studies (GWAS) have identified more …
Molecular regulation of G protein localization and its pharmacological implications
MI Tennakoon - 2022 - rave.ohiolink.edu
By transmitting external signals to the cell interior, guanine nucleotide-binding proteins (G
proteins) regulate most eukaryotic signaling and thus have become crucial disease drivers …
proteins) regulate most eukaryotic signaling and thus have become crucial disease drivers …