Transcription of DNA is a fundamental process in all cellular organisms. The enzyme
responsible for transcription, RNA polymerase, is conserved in general architecture and …

Bacterial signal transduction systems are responsible for sensing environmental cues and
adjusting the cellular behaviour and/or metabolism in response to these cues. They also …

Autoproteolysis has been discovered to play key roles in various biological processes, but
functional autoproteolysis has been rarely reported for transmembrane signaling in …

CRISPR defence systems such as the well-known DNA-targeting Cas9 and the RNA-
targeting type III systems are widespread in prokaryotes,. The latter orchestrates a complex …

Phocaeicola vulgatus is one of the most abundant and ubiquitous bacterial species of the
human gut microbiota, yet a comprehensive analysis of antibacterial toxin production by …

Responding to environmental cues is a prerequisite for survival in the microbial world.
Extracytoplasmic function σ factors (ECFs) represent the third most abundant and by far the …

Lactic acid bacteria (LAB) encompasses industrially relevant bacteria involved in food
fermentations as well as health-promoting members of our autochthonous microbiota. In the …

The emerging human enteropathogen Clostridioides difficile is the main cause of diarrhea
associated with antibiotherapy. Regulatory pathways underlying the adaptive responses …

Extracytoplasmic (ECF) σ factors, the largest class of alternative σ factors, are related to
primary σ factors, but have simpler structures, comprising only two of six conserved …

Antibiotics that inhibit peptidoglycan synthesis trigger the activation of both specific and
general protective responses. σM responds to diverse antibiotics that inhibit cell wall …