Gut Bacteroides species in health and disease

H Zafar, MH Saier Jr - Gut microbes, 2021 - Taylor & Francis
The functional diversity of the mammalian intestinal microbiome far exceeds that of the host
organism, and microbial genes contribute substantially to the well-being of the host …

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

P Paone, PD Cani - Gut, 2020 - gut.bmj.com
The gastrointestinal tract is often considered as a key organ involved in the digestion of food
and providing nutrients to the body for proper maintenance. However, this system is …

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

EC Martens, M Neumann, MS Desai - Nature Reviews Microbiology, 2018 - nature.com
The intestinal mucosal barrier is composed of epithelial cells that are protected by an
overlying host-secreted mucous layer and functions as the first line of defence against …

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

MR Kudelka, SR Stowell, RD Cummings… - Nature reviews …, 2020 - nature.com
Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …

Global functions of O‐glycosylation: promises and challenges in O‐glycobiology

HH Wandall, MAI Nielsen, S King‐Smith… - The FEBS …, 2021 - Wiley Online Library
Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

Mucin glycan foraging in the human gut microbiome

LE Tailford, EH Crost, D Kavanaugh, N Juge - Frontiers in genetics, 2015 - frontiersin.org
The availability of host and dietary carbohydrates in the gastrointestinal (GI) tract plays a key
role in shaping the structure-function of the microbiota. In particular, some gut bacteria have …

Potential of fecal microbiota for early‐stage detection of colorectal cancer

G Zeller, J Tap, AY Voigt, S Sunagawa… - Molecular systems …, 2014 - embopress.org
Several bacterial species have been implicated in the development of colorectal carcinoma
(CRC), but CRC‐associated changes of fecal microbiota and their potential for cancer …

The role of the gastrointestinal mucus system in intestinal homeostasis: implications for neurological disorders

M Herath, S Hosie, JC Bornstein, AE Franks… - Frontiers in cellular …, 2020 - frontiersin.org
Mucus is integral to gut health and its properties may be affected in neurological disease.
Mucus comprises a hydrated network of polymers including glycosylated mucin proteins. We …

Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice

P Wang, D Li, W Ke, D Liang, X Hu… - International Journal of …, 2020 - nature.com
Objective Resveratrol (RSV) is a natural polyphenol with putative anti-obesity effects;
however, its mechanisms of action remain unclear due to its low bioavailability. Microbial …

Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases

LJ Spielman, DL Gibson, A Klegeris - Neurochemistry international, 2018 - Elsevier
The number of bacterial cells living within the human body is approximately equal to, or
greater than, the total number of human cells. This dynamic population of microorganisms …