Kerr et al (1) in 1972 coined the term “apoptosis,” an ancient Greek word used to describe
the “falling off” of leaves from trees or petals from flowers, referring to the particular …

Having evolved to generate a huge Ag-specific repertoire and to mount T cell-dependent
responses and long-term memory, the B lymphocyte is a central player in the adaptive …

Abstract Objective Peripheral blood lymphocytes (PBLs) from systemic lupus erythematosus
(SLE) patients exhibit increased spontaneous and diminished activation‐induced apoptosis …

The objective of the study was that the regulatory T cells (Treg) that specialize in the
suppression of immune responses might be critically involved in the pathogenesis of …

Abstract CD4+ CD25+ Foxp3+ regulatory T cells (Treg) that specialize in the suppression of
immune responses might be critically involved in the pathogenesis of autoimmune diseases …

Abnormal death signaling in lymphocytes of systemic lupus erythematosus (SLE) patients
has been associated with elevation of the mitochondrial transmembrane potential (Δψ m) …

The production of high-affinity pathogenic autoantibodies in systemic lupus erythematosus
(SLE) may result from aberrant immune regulation. Since 1, 25 dihydroxy vitamin D3 (1, 25 …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized
by diverse cellular and biochemical aberrations, including decreased production of IL-2 …

Systemic lupus erythematosus (SLE) is characterized by abnormalities in T lymphocyte
receptor–mediated signal transduction pathways. Our previous studies have established …

Objective T cells from the majority of patients with systemic lupus erythematosus (SLE)
express significantly lower levels of T cell receptor ζ chain, a critical signaling molecule …