Neutrophil diversity in health and disease

C Silvestre-Roig, ZG Fridlender, M Glogauer… - Trends in …, 2019 - cell.com
New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Update on neutrophil function in severe inflammation

E Mortaz, SD Alipoor, IM Adcock, S Mumby… - Frontiers in …, 2018 - frontiersin.org
Neutrophils are main players in the effector phase of the host defense against micro-
organisms and have a major role in the innate immune response. Neutrophils show …

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

Z Lv, X Xu, Z Sun, YX Yang, H Guo, J Li, K Sun… - Cell death & …, 2021 - nature.com
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven
synovitis exacerbates the pathological process. However, precise therapies for M1 …

Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease

R Grieshaber-Bouyer, PA Nigrovic - Frontiers in immunology, 2019 - frontiersin.org
Neutrophils are versatile innate effector cells essential for immune defense but also
responsible for pathologic inflammation. This dual role complicates therapeutic targeting …

Neutrophil phenotypes in health and disease

P Hellebrekers, N Vrisekoop… - European journal of …, 2018 - Wiley Online Library
Neutrophils are one of the most important effector cells of the innate immune response (1).
They are traditionally seen as a homogenous population of short‐lived cells mainly involved …

The neutrophil: one cell on many missions or many cells with different agendas?

G Christoffersson, M Phillipson - Cell and tissue research, 2018 - Springer
The unique role of neutrophils in host defense is not only based on their abilities to kill
bacteria but is also due to their abundance in circulation and their ability to quickly migrate …

Cyclosporine modulates neutrophil functions via the SIRT6–HIF‐1α–glycolysis axis to alleviate severe ulcerative colitis

H Lu, J Lin, C Xu, M Sun, K Zuo… - Clinical and …, 2021 - Wiley Online Library
Abstract Background Cyclosporine A (CsA) is routinely used to treat patients with steroid‐
refractory acute severe ulcerative colitis (ASUC). Here, we studied the underlying …

TAS2R16 activation suppresses LPS-induced cytokine expression in human gingival fibroblasts

Z Zhou, R Xi, J Liu, X Peng, L Zhao, X Zhou… - Frontiers in …, 2021 - frontiersin.org
Sustained and non-resolved inflammation is a characteristic of periodontitis. Upon acute
inflammation, gingival fibroblasts release cytokines to recruit immune cells to counter …

Mechanisms of immune checkpoint inhibitor-mediated colitis

H Westdorp, MWD Sweep, MAJ Gorris… - Frontiers in …, 2021 - frontiersin.org
Immune checkpoint inhibitors (ICIs) have provided tremendous clinical benefit in several
cancer types. However, systemic activation of the immune system also leads to several …

Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis

JS Moon, CC Ho, JH Park, K Park, BY Shin… - Nature …, 2023 - nature.com
Regulatory T cells (Treg) are CD4+ T cells with immune-suppressive function, which is
defined by Foxp3 expression. However, the molecular determinants defining the …