Fetal alcohol spectrum disorders: a review of the neurobehavioral deficits associated with prenatal alcohol exposure

SN Mattson, GA Bernes… - Alcoholism: Clinical and …, 2019 - Wiley Online Library
In utero alcohol exposure can disrupt the development of the fetal brain and result in a wide
range of neurobehavioral outcomes collectively known as fetal alcohol spectrum disorders …

Prenatal and postnatal choline supplementation in fetal alcohol spectrum disorder

AM Ernst, BA Gimbel, E de Water, JK Eckerle… - Nutrients, 2022 - mdpi.com
Fetal alcohol spectrum disorder (FASD) is common and represents a significant public
health burden, yet very few interventions have been tested in FASD. Cognitive deficits are …

Efficacy of maternal choline supplementation during pregnancy in mitigating adverse effects of prenatal alcohol exposure on growth and cognitive function: a …

SW Jacobson, RC Carter, CD Molteno… - Alcoholism: Clinical …, 2018 - Wiley Online Library
Background We recently demonstrated the acceptability and feasibility of a randomized,
double‐blind choline supplementation intervention for heavy drinking women during …

FASDetect as a machine learning-based screening app for FASD in youth with ADHD

L Ehrig, AC Wagner, H Wolter, CU Correll… - npj Digital …, 2023 - nature.com
Fetal alcohol-spectrum disorder (FASD) is underdiagnosed and often misdiagnosed as
attention-deficit/hyperactivity disorder (ADHD). Here, we develop a screening tool for FASD …

Fetal alcohol growth restriction and cognitive impairment

RC Carter, JL Jacobson, CD Molteno, NC Dodge… - …, 2016 - publications.aap.org
BACKGROUND: Although both fetal and long-term growth restriction are well documented in
fetal alcohol spectrum disorders, effects on pattern of growth trajectory have not been …

Effects of moderate prenatal alcohol exposure during early gestation in rats on inflammation across the maternal-fetal-immune interface and later-life immune function …

LS Terasaki, JM Schwarz - Journal of Neuroimmune Pharmacology, 2016 - Springer
During early brain development, microglial activation can negatively impact long-term
neuroimmune and cognitive outcomes. It is well-known that significant alcohol exposure …

Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes

FL Warton, CD Molteno, CMR Warton… - Alcoholism: Clinical …, 2021 - Wiley Online Library
Background Prenatal alcohol exposure (PAE) is associated with smaller regional and global
brain volumes. In rats, gestational choline supplementation mitigates adverse …

Effects of prenatal alcohol exposure on cognitive and behavioral development: Findings from a hierarchical meta‐analysis of data from six prospective longitudinal US …

JL Jacobson, T Akkaya‐Hocagil… - Alcoholism: Clinical …, 2021 - Wiley Online Library
Background Cognitive and behavioral sequelae of prenatal alcohol exposure (PAE)
continue to be prevalent in the United States and worldwide. Because these sequelae are …

Hippocampal deficits in neurodevelopmental disorders

Y Li, M Shen, ME Stockton, X Zhao - Neurobiology of learning and memory, 2019 - Elsevier
Neurodevelopmental disorders result from impaired development or maturation of the
central nervous system. Both genetic and environmental factors can contribute to the …

White matter deficits mediate effects of prenatal alcohol exposure on cognitive development in childhood

J Fan, SW Jacobson, PA Taylor… - Human Brain …, 2016 - Wiley Online Library
Fetal alcohol spectrum disorders comprise the spectrum of cognitive, behavioral, and
neurological impairments caused by prenatal alcohol exposure (PAE). Diffusion tensor …