The clinical progress of mRNA vaccines and immunotherapies

AJ Barbier, AY Jiang, P Zhang, R Wooster… - Nature …, 2022 - nature.com
The emergency use authorizations (EUAs) of two mRNA-based severe acute respiratory
syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after publication of …

Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection

D Cromer, JA Juno, D Khoury, A Reynaldi… - Nature Reviews …, 2021 - nature.com
Immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is
central to long-term control of the current pandemic. Despite our rapidly advancing …

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Y Peng, AJ Mentzer, G Liu, X Yao, Z Yin, D Dong… - Nature …, 2020 - nature.com
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines and therapeutics will depend on understanding viral immunity. We studied T cell …

SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity

JME Lim, AT Tan, N Le Bert, SK Hang… - Journal of Experimental …, 2022 - rupress.org
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+
and CD4+ T cells of broad specificity | Journal of Experimental Medicine | Rockefeller …

The evolving role of tissue-resident memory T cells in infections and cancer

S Yenyuwadee, JL Sanchez-Trincado Lopez… - Science …, 2022 - science.org
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

Activation or exhaustion of CD8+ T cells in patients with COVID-19

MS Rha, EC Shin - Cellular & molecular immunology, 2021 - nature.com
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …

SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals

H Kared, AD Redd, EM Bloch, TS Bonny… - The Journal of …, 2021 - Am Soc Clin Investig
Characterization of the T cell response in individuals who recover from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical to understanding its …

The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues

L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …

Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters

L Zhang, Y Jiang, J He, J Chen, R Qi, L Yuan… - Nature …, 2023 - nature.com
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
and “anatomical escape” characteristics threaten the effectiveness of current coronavirus …