The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Transcription factors (TFs) regulate gene expression by binding to DNA sequences and
modulating transcriptional activity through their effector domains. Despite the central role of …

The transcription factor PAX6 is essential in ocular development in vertebrates, being
considered the master regulator of the eye. During eye development, it is essential for the …

The transcriptional regulation of neuroectoderm (NE) specification is unknown. Here we
show that Pax6 is uniformly expressed in early NE cells of human fetuses and those …

The Pax gene family encodes a group of transcription factors that have been conserved
through millions of years of evolution and play roles in early development. Pax proteins have …

Pax6 is a highly conserved transcription factor among vertebrates and is important in various
developmental processes in the central nervous system (CNS), including patterning of the …

▪ Abstract Alternative splicing of pre-mRNAs is a powerful and versatile regulatory
mechanism that can effect quantitative control of gene expression and functional …

Type 2 diabetes is thought to involve a compromised β cell differentiation state, but the
mechanisms underlying this dysfunction remain unclear. Here, we report a key role for the …

Pax6 is a key transcription factor in eye development, particularly in lens development, but
its molecular action has not been clarified. We demonstrate that Pax6 initiates lens …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …