Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of
ion channels located in the membranes of all cells and many cellular organelles. These …

Messenger RNA (mRNA) technology has already been successfully tested preclinically and
there are ongoing clinical trials for protein replacement purposes; however, more effort has …

The kidney is the central organ involved in maintaining water and sodium balance. In human
kidneys, nine aquaporins (AQPs), including AQP1–8 and AQP11, have been found and are …

Arginine vasopressin (AVP) plays a key role in many physiologic and pathologic processes.
The most important stimulus for AVP release is a change in plasma osmolality. AVP is also …

Diabetes insipidus (DI) is an endocrine condition involving the posterior pituitary peptide
hormone, antidiuretic hormone (ADH). ADH exerts its effects on the distal convoluted tubule …

G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma
membrane seven times (hence, are also called 7TM receptors). The polytopic structure of …

Highlights•Structural studies of aquaporins give new insights into selectivity and regulation.•
Subångström resolution structure yeast Aqy1 revises the proton exclusion mechanism.•A …

Human aquaporin 2 (AQP2) is a water channel found in the kidney collecting duct, where it
plays a key role in concentrating urine. Water reabsorption is regulated by AQP2 trafficking …

Under physiological conditions, excessive loss of water through the urine is prevented by
the release of the antidiuretic hormone arginine-vasopressin (AVP) from the posterior …