We have determined the complete 1,694,969-nt sequence of the GC-rich genome of
Methanopyrus kandleri by using a whole direct genome sequencing approach. This …

Primary microcephaly (MCPH) is a neurodevelopmental disorder characterized by global
reduction in cerebral cortical volume. The microcephalic brain has a volume comparable to …

In recent years modified oligonucleotides (oligos) have become an area of increased
research activity. These synthetic biopolymers have long been used as molecular probes to …

Germ-line mutations in the BRCA1 gene predispose affected individuals to breast and
ovarian cancer syndromes. In an attempt to systematically analyze a broader spectrum of …

We have completely sequenced and annotated the genomes of several relatives of the
bacteriophage T4, including three coliphages (RB43, RB49 and RB69), three Aeromonas …

The reported human genome sequence includes about 400 gaps of unknown sequence that
were not found in the bacterial artificial chromosome (BAC) and cosmid libraries used for …

The reported draft human genome sequence includes many contigs that are separated by
gaps of unknown sequence. These gaps may be due to chromosomal regions that are not …

ZAZE_ENP 701..733 Page 1 Abstract. The known methods for the synthesis of 2H-functionalised
nucleosides, oligonucleotides and their conjugates are systematised. The applications of 2H-modified …

A typical “working draft” bacterial artificial chromosome (BAC) project consists of approx
2000 shotgun reads obtained from a library of M13 or plasmid subclones that provide 2–5X …

We describe synthesis of four novel biotin phosphoramidites with tethering arms ranging
from 20 to 74 atoms in length. One of these phosphoramidites is a uridine derivative with a …