This article describes current experimental models of status epilepticus (SE) and neuronal
injury for use in the screening of new therapeutic agents. Epilepsy is a common neurological …

Axonal damage has recently been recognized to be a key predictor of outcome in a number
of diverse human CNS diseases, including head and spinal cord trauma, metabolic …

The dentate granule cell layer of the rodent hippocampal formation has the distinctive
property of ongoing neurogenesis that continues throughout adult life. In both human …

Damage to axons is taken as a key factor of disability in multiple sclerosis, but its
pathogenesis is largely unknown. Axonal injury is believed to occur as a consequence of …

Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of
movement disorders and an emerging therapeutic approach for the treatment of disorders of …

To address genetic influences on hippocampal neurogenesis in adult mice, we compared
C57BL/6, BALB/c, CD1 (ICR), and 129Sv/J mice to examine proliferation, survival, and …

Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of
human limbic epilepsy. Five hours after one hippocampal kindling stimulation, a marked …

Fast synaptic inhibition in the forebrain is mediated primarily by GABA acting on GABAA
receptors (GABARs). GABARs are regulated by numerous positive (barbiturates …

Mitochondrial dysfunction has been implicated as a contributing factor in diverse acute and
chronic neurological disorders. However, its role in the epilepsies has only recently …

Epilepsies are a diverse collection of brain disorders that affect 1–2% of the population.
Current therapies are unsatisfactory as they provide only symptomatic relief, are effective in …