There is limited knowledge on durability of neutralization capacity and antibody affinity
maturation generated following two versus three doses of SARS-CoV-2 mRNA vaccines in …

Avidity of immunoglobulin G (IgG) is defined as its binding strength to its target antigen. As a
consequence of affinity maturation of the IgG response, avidity is maturing as well …

Several vaccines are approved in the United States for seasonal influenza vaccination every
year. Here we compare the impact of repeat influenza vaccination on hemagglutination …

Immune responses to inactivated vaccines against avian influenza are poor due in part to
lack of immune memory. Adjuvants significantly increased virus neutralizing titers. We …

Background Limited knowledge exists regarding antibody affinity maturation following
mRNA vaccination in naïve vs. COVID-19 recovered individuals and potential sex …

Mucosal immunity plays a key role in prevention of SARS-CoV-2 virus spread to the lungs. In
this study, we evaluated systemic and mucosal immune signatures in asymptomatic SARS …

Vaccination is by far the most effective way of preventing morbidity and mortality due to
infection of the upper respiratory tract by influenza virus. Current vaccines require yearly …

Memory B cells (MBCs) are key determinants of the B cell response to influenza virus
infection and vaccination, but the effect of different forms of influenza antigen exposure on …

In a phase 1 randomized, single-center clinical trial, inactivated influenza virus vaccine
delivered through dissolvable microneedle patches (MNPs) was found to be safe and …

In an open label clinical study (2007), MF59-adjuvanted hemagglutinin (HA) vaccine from
H5N1-A/Vietnam/1194/2004 (clade 1) was administered to subjects previously vaccinated …