The therapeutic potential of metformin in neurodegenerative diseases

C Rotermund, G Machetanz… - Frontiers in endocrinology, 2018 - frontiersin.org
The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …

TRAP1 in oxidative stress and neurodegeneration

I Ramos Rego, B Santos Cruz, AF Ambrósio, CH Alves - Antioxidants, 2021 - mdpi.com
Tumor necrosis factor receptor-associated protein 1 (TRAP1), also known as heat shock
protein 75 (HSP75), is a member of the heat shock protein 90 (HSP90) chaperone family …

Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer's disease

Y Zhang, Y Miao, J Tan, F Chen, P Lei… - Journal of Translational …, 2023 - Springer
Background Alzheimer's disease (AD) is the most common neurodegenerative disease.
Mitochondrial dysfunction and immune responses are important factors in the pathogenesis …

TRAP1: A Metabolic Hub Linking Aging Pathophysiology to Mitochondrial S-Nitrosylation

F Faienza, S Rizza, P Giglio, G Filomeni - Frontiers in Physiology, 2020 - frontiersin.org
Tumor necrosis factor receptor-associated protein 1 (TRAP1), also known as heat shock
protein 75 (Hsp75), is the mitochondrial member of the Hsp90 family of molecular …

Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson's disease

JC Fitzgerald, A Zimprich, D Reddy Bobbili, M Sharma… - Brain, 2018 - academic.oup.com
Sir, In their letter in this issue, Gaare and colleagues (2018) state that TRAP1 may not be a
Parkinson's disease gene because of lack of genetic association. In response, we welcome …

[PDF][PDF] Systematic analysis of rare variants in mitochondrial function-associated genes for autosomal-dominant Parkinson's disease in a Chinese population

Y Chen, X Gu, R Ou, L Zhang, Y Hou, K Liu, B Cao… - 2020 - pdfs.semanticscholar.org
Systematic analysis of rare variants in mitochondrial function-associated genes for
autosomal-dominant Parkinson’s disease in Page 1 Page 1/25 Systematic analysis of rare …