Local delivery and controlled release drugs systems: a new approach for the clinical treatment of periodontitis therapy

M Amato, S Santonocito, A Polizzi, GM Tartaglia… - Pharmaceutics, 2023 - mdpi.com
Periodontitis is an inflammatory disease of the gums characterized by the degeneration of
periodontal ligaments, the formation of periodontal pockets, and the resorption of the …

Drug release from in situ forming implants and advances in release testing

X Wang, DJ Burgess - Advanced Drug Delivery Reviews, 2021 - Elsevier
In situ forming implants, defined as liquid formulations that generate solid or semisolid
depots following administration, have shown a range of advantages in drug delivery. This …

Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review

Y Wei, Y Deng, S Ma, M Ran, Y Jia, J Meng… - Journal of Controlled …, 2021 - Elsevier
Periodontitis is a chronic inflammation of the soft tissue surrounding and supporting the
teeth, which causes periodontal structural damage, alveolar bone resorption, and even tooth …

Quality by design for development, optimization and characterization of brucine ethosomal gel for skin cancer delivery

TA Ismail, TM Shehata, DI Mohamed, HS Elsewedy… - Molecules, 2021 - mdpi.com
Natural products have been extensively used for treating a wide variety of disorders. In
recent times, Brucine (BRU) as one of the natural medications extracted from seeds of nux …

Solid lipid nanoparticles for transdermal delivery of avanafil: optimization, formulation, in-vitro and ex-vivo studies

M Kurakula, OAA Ahmed, UA Fahmy… - Journal of liposome …, 2016 - Taylor & Francis
Context: Avanafil (AVA) is used in the treatment of erectile dysfunction, but is reported for its
poor aqueous solubility. Solid lipid nanoparticles (SLNs) are lipid carriers that can greatly …

Local drug delivery systems for inflammatory diseases: Status quo, challenges, and opportunities

YC Chen, SF Gad, D Chobisa, Y Li, Y Yeo - Journal of Controlled Release, 2021 - Elsevier
Inflammation that is not resolved in due course becomes a chronic disease. The treatment of
chronic inflammatory diseases involves a long-term use of anti-inflammatory drugs such as …

Quality by design for optimizing a novel liposomal jojoba oil-based emulgel to ameliorate the anti-inflammatory effect of brucine

MH Abdallah, HS Elsewedy, AS AbuLila, K Almansour… - Gels, 2021 - mdpi.com
One of the recent advancements in research is the application of natural products in
developing newly effective formulations that have few drawbacks and that boost therapeutic …

Date Palm Extract (Phoenix dactylifera) PEGylated Nanoemulsion: Development, Optimization and Cytotoxicity Evaluation

HE Khalil, NK Alqahtani, HM Darrag, HIM Ibrahim… - Plants, 2021 - mdpi.com
Date palm fruit (Phoenix dactylifera) is reputed to have numerous biological activities,
including anticancer properties. To utilize the great fortune of this fruit, the current study …

Development, characterization and optimization of the anti-inflammatory influence of meloxicam loaded into a eucalyptus oil-based nanoemulgel

TM Shehata, HM Elnahas, HS Elsewedy - Gels, 2022 - mdpi.com
The purpose of the present study was to explore the influence of a certain natural essential
oil, namely eucalyptus oil, as an anti-inflammatory agent in addition to its prospective role in …

Novel formulation of fusidic acid incorporated into a myrrh-oil-based nanoemulgel for the enhancement of skin bacterial infection treatment

MM Almostafa, HS Elsewedy, TM Shehata… - Gels, 2022 - mdpi.com
Fusidic acid (FA) is renowned as an effective bacteriostatic agent obtained from the fungus
Fusidium coccineum, used for treating various eye and skin disorders. The objective of the …