Mutant p53: one name, many proteins
WA Freed-Pastor, C Prives - Genes & development, 2012 - genesdev.cshlp.org
There is now strong evidence that mutation not only abrogates p53 tumor-suppressive
functions, but in some instances can also endow mutant proteins with novel activities. Such …
functions, but in some instances can also endow mutant proteins with novel activities. Such …
[HTML][HTML] Transcriptional regulation by p53: one protein, many possibilities
O Laptenko, C Prives - Cell Death & Differentiation, 2006 - nature.com
The p53 tumor suppressor protein is a DNA sequence-specific transcriptional regulator that,
in response to various forms of cellular stress, controls the expression of numerous genes …
in response to various forms of cellular stress, controls the expression of numerous genes …
[HTML][HTML] Structural basis of DNA recognition by p53 tetramers
M Kitayner, H Rozenberg, N Kessler, D Rabinovich… - Molecular cell, 2006 - cell.com
The tumor-suppressor protein p53 is among the most effective of the cell's natural defenses
against cancer. In response to cellular stress, p53 binds as a tetramer to diverse DNA targets …
against cancer. In response to cellular stress, p53 binds as a tetramer to diverse DNA targets …
p53 contains large unstructured regions in its native state
S Bell, C Klein, L Müller, S Hansen… - Journal of molecular …, 2002 - Elsevier
The human tumor suppressor protein p53 is understood only to some extent on a structural
level. We performed a comprehensive biochemical and biophysical structure–function …
level. We performed a comprehensive biochemical and biophysical structure–function …
[HTML][HTML] Molecular docking studies, drug-likeness and in-silico ADMET prediction of some novel β-Amino alcohol grafted 1, 4, 5-trisubstituted 1, 2, 3-triazoles …
Malaria is a killer disease caused by Plasmodium falciparum and is responsible for over a
million death annually. Chloroquine, quinine, pyrimethamine, proguanil, artemisinin …
million death annually. Chloroquine, quinine, pyrimethamine, proguanil, artemisinin …
Intrinsically disordered regions as affinity tuners in protein–DNA interactions
D Vuzman, Y Levy - Molecular BioSystems, 2012 - pubs.rsc.org
Intrinsically disordered regions, terminal tails, and flexible linkers are abundant in DNA-
binding proteins and play a crucial role by increasing the affinity and specificity of DNA …
binding proteins and play a crucial role by increasing the affinity and specificity of DNA …
The N-terminal domain of p53 is natively unfolded
R Dawson, L Müller, A Dehner, C Klein… - Journal of molecular …, 2003 - Elsevier
p53 is one of the key molecules regulating cell proliferation, apoptosis and tumor
suppression by integrating a wide variety of signals. The structural basis for this function is …
suppression by integrating a wide variety of signals. The structural basis for this function is …
[HTML][HTML] p53 linear diffusion along DNA requires its C terminus
K McKinney, M Mattia, V Gottifredi, C Prives - Molecular cell, 2004 - cell.com
In cells, sequence-specific transcription factors must search through an entire genome to
find their target sites in promoters. Such sites may be identified by using one-dimensional …
find their target sites in promoters. Such sites may be identified by using one-dimensional …
The C terminus of p53 binds the N-terminal domain of MDM2
MV Poyurovsky, C Katz, O Laptenko… - Nature structural & …, 2010 - nature.com
The p53 tumor suppressor interacts with its negative regulator Mdm2 via the former's N-
terminal region and core domain, yet the extreme p53 C-terminal region contains lysine …
terminal region and core domain, yet the extreme p53 C-terminal region contains lysine …