Phytochemicals involved in mitigating silent toxicity induced by heavy metals

J Ceramella, AC De Maio, G Basile, A Facente, E Scali… - Foods, 2024 - mdpi.com
Heavy metals (HMs) are natural elements present in the Earth's crust, characterised by a
high atomic mass and a density more than five times higher than water. Despite their origin …

Testicular protective effects of hesperidin against chemical and biological toxicants

L Yan, J Wang, D Dai, Y Zhang, Y Li… - Toxicology …, 2024 - academic.oup.com
Toxic agents can adversely impact the male reproductive system mainly via activating
oxidative stress affecting the seminiferous epithelia, spermatogenesis, sperms, and the …

Urtica pilulifera leaves extract mitigates cadmium induced hepatotoxicity via modulation of antioxidants, inflammatory markers and Nrf-2 signaling in mice

S Hussein, A Ben Bacha, M Alonazi… - Frontiers in Molecular …, 2024 - frontiersin.org
Introduction: Cadmium (Cd) is a harmful heavy metal that results in many toxic issues. Urtica
pilulifera showed potential pharmaceutical applications. This study investigated the possible …

[HTML][HTML] Targeting JAK2/STAT3, NLRP3/Caspase-1, and PK2/PKR2 Pathways with Arbutin Ameliorates Lead Acetate-Induced Testicular Injury in Rats

HH Arab, SE Alsufyani, AM Ashour, AM Gad… - Pharmaceuticals, 2024 - mdpi.com
The reproductive system of males is adversely impacted by lead (Pb), a toxic heavy metal.
The present study examined arbutin, a promising hydroquinone glycoside, for its potential …

10-Hydroxy Decanoic Acid and Zinc Oxide Nanoparticles Retrieve Nrf2/HO-1 and Caspase-3/Bax/Bcl-2 Signaling in Lead-Induced Testicular Toxicity

AM Maher, GA Elsanosy, DA Ghareeb… - … Trace Element Research, 2024 - Springer
There has been a significant increase in human exposure to heavy metals (HMs) over the
course of the previous century, primarily due to the extensive industrial processes. Male …

[HTML][HTML] Screening of bioactive components in Ferula assafo dried oleo-gum resin and assessment of its protective function against cadmium-induced oxidative …

HE Mohammed, AA El-Nekeety, HM Rashwan… - Toxicology Reports, 2025 - Elsevier
Cadmium (Cd) is among the most ecologically harmful heavy metals. The purpose of this
work was to identify the biologically active components in dried oleo-resin-gum of Ferula …

Annona squamosa Fruit Extract Ameliorates Lead Acetate-Induced Testicular Injury by Modulating JAK-1/STAT-3/SOCS-1 Signaling in Male Rats

MA Mobasher, AM Alsirhani, MA Alwaili… - International Journal of …, 2024 - mdpi.com
Lead (Pb) is a common pollutant that is not biodegradable and gravely endangers the
environment and human health. Annona squamosa fruit has a wide range of medicinal uses …

[HTML][HTML] Effect of hesperidin in the prevention of aluminum chloride-induced testicular dysfunction in rats

S Parasuraman, LY Huey, YS Jee - Journal of Advanced …, 2024 - journals.lww.com
Hesperidin is a citrus bioflavonoid and has numerous pharmacological actions. Hesperidin's
effect on testicular dysfunction has not been well researched. Hence, the present study is …