What do drug transporters really do?
SK Nigam - Nature reviews Drug discovery, 2015 - nature.com
Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …
Gut bacteria signaling to mitochondria in intestinal inflammation and cancer
DN Jackson, AL Theiss - Gut microbes, 2020 - Taylor & Francis
The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …
intestine as well as in the pathophysiology of diseases including inflammatory bowel …
Mitochondrial function—gatekeeper of intestinal epithelial cell homeostasis
E Rath, A Moschetta, D Haller - Nature reviews Gastroenterology & …, 2018 - nature.com
The intestinal epithelium is a multicellular interface in close proximity to a dense microbial
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …
The SLC transporter in nutrient and metabolic sensing, regulation, and drug development
Y Zhang, Y Zhang, K Sun, Z Meng… - Journal of molecular cell …, 2019 - academic.oup.com
The prevalence of metabolic diseases is growing worldwide. Accumulating evidence
suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic …
suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic …
The SLC22 family with transporters of organic cations, anions and zwitterions
H Koepsell - Molecular aspects of medicine, 2013 - Elsevier
The SLC22 family contains 13 functionally characterized human plasma membrane proteins
each with 12 predicted α-helical transmembrane domains. The family comprises organic …
each with 12 predicted α-helical transmembrane domains. The family comprises organic …
Mitochondria, the gut microbiome and ROS
JWO Ballard, SG Towarnicki - Cellular signalling, 2020 - Elsevier
In this review, we discuss the connections between mitochondria and the gut microbiome
provided by reactive oxygen species (ROS). We examine the mitochondrion as an …
provided by reactive oxygen species (ROS). We examine the mitochondrion as an …
Mitochondrial dysfunction in inflammatory bowel disease
EA Novak, KP Mollen - Frontiers in cell and developmental biology, 2015 - frontiersin.org
Inflammatory Bowel Disease (IBD) represents a group of idiopathic disorders characterized
by chronic or recurring inflammation of the gastrointestinal tract. While the exact etiology of …
by chronic or recurring inflammation of the gastrointestinal tract. While the exact etiology of …
Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn's disease recurrence
S Khaloian, E Rath, N Hammoudi, E Gleisinger… - Gut, 2020 - gut.bmj.com
Objective Reduced Paneth cell (PC) numbers are observed in inflammatory bowel diseases
and impaired PC function contributes to the ileal pathogenesis of Crohn's disease (CD). PCs …
and impaired PC function contributes to the ileal pathogenesis of Crohn's disease (CD). PCs …
Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1
ABSTRACT Purpose Solute carrier OCTN1 (SLC22A4) is an orphan transporter, the
physiologically important substrate of which is still unidentified. The aim of the present study …
physiologically important substrate of which is still unidentified. The aim of the present study …
The druggability of solute carriers
The transport of materials across membranes is a vital process for all aspects of cellular
function, including growth, metabolism, and communication. Protein transporters are the …
function, including growth, metabolism, and communication. Protein transporters are the …