The gastrointestinal tract presents the largest and most vulnerable surface to the outside
world. Simultaneously, it must be accessible and permeable to nutrients and must defend …

The intestinal epithelium must balance efficient absorption of nutrients with partitioning
commensals and pathogens from the bodies' largest immune system. If this crucial barrier …

Summary Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L
cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also …

Host sensing in the gut microbiota has been crucial in the regulation of intestinal
homeostasis. Although inflammatory bowel diseases (IBDs), multifactorial chronic …

Obesity and diabetes are characterized by increased inflammation reflecting disordered
control of innate immunity. We reveal a local intestinal intraepithelial lymphocyte (IEL)-GLP …

The enteroendocrine system is the primary sensor of ingested nutrients and is responsible
for secreting an array of gut hormones, which modulate multiple physiological responses …

Enteroendocrine cells (EEs) are interspersed between enterocytes and stem cells in the
Drosophila intestinal epithelium. Like enterocytes, EEs express components of the immune …

Abstract Interleukin-32 (IL-32) is a novel cytokine involved in inflammation and cancer
development. IL-32 gene consists of eight small exons, and IL-32 mRNA has nine …

There are more than 2 billion overweight and obese individuals worldwide, surpassing for
the first time, the number of people affected by undernutrition. Obesity and its comorbidities …

Chronic diseases, such as obesity and diabetes, cardiovascular, and inflammatory bowel
diseases (IBD) share common features in their pathology. Metabolic disorders exhibit strong …