Production of radiometals in liquid targets

SJC Do Carmo, PJH Scott, F Alves - EJNMMI Radiopharmacy and …, 2020 - Springer
Over the last several years, the use of radiometals has gained increasing relevance in
supporting the continuous development of new, complementary and more specific biological …

Purification of Copper Radioisotopes for Medical Applications: Chromatographic Methods and Challenges

AI Fonseca, SJC Do Carmo, I Hrynchak… - Separation & …, 2024 - Taylor & Francis
Copper radioisotopes are gaining increasing significance for medical use in recent years for
both diagnostic and therapeutic applications. To answer the growing clinical demand, fast …

Production of GMP-compliant clinical amounts of Copper-61 radiopharmaceuticals from liquid targets

AI Fonseca, VH Alves, SJC do Carmo, M Silva… - Pharmaceuticals, 2022 - mdpi.com
PET imaging has gained significant momentum in the last few years, especially in the area
of oncology, with an increasing focus on metal radioisotopes owing to their versatile …

[HTML][HTML] Cross-section measurement for an optimized 61Cu production at an 18 MeV medical cyclotron from natural Zn and enriched 64Zn solid targets

G Dellepiane, P Casolaro, I Mateu, P Scampoli… - Applied Radiation and …, 2022 - Elsevier
The availability of novel medical radionuclides is a key point in the development of
personalised nuclear medicine. In particular, copper radioisotopes are attracting …

Automated purification of radiometals produced by liquid targets

VH Alves, SJC Do Carmo, F Alves, AJ Abrunhosa - Instruments, 2018 - mdpi.com
An automated process for the production and purification of radiometals produced by
irradiating liquid targets in a medical cyclotron, using a commercially available module, has …

Evaluated and recommended cross-section data for production of radionuclides with emerging interest in nuclear medicine imaging. Part 1: Positron emission …

A Hermanne, FT Tárkányi, AV Ignatyuk… - Nuclear Instruments and …, 2023 - Elsevier
Evaluated reactions for production of thirteen radionuclides with emerging interest for use in
PET imaging are reported. Experimental cross section data for 53 possible production routes …

Photoactivatable bis (thiosemicarbazone) derivatives for copper-64 radiotracer synthesis

DF Earley, JE Flores, A Guillou, JP Holland - Dalton Transactions, 2022 - pubs.rsc.org
In recent years, copper-64 and copper-67 have been considered as a useful theranostic pair
in nuclear medicine, due to their favourable and complementary decay properties. As 67Cu …

Production of a broad palette of positron emitting radioisotopes using a low-energy cyclotron: Towards a new success story in cancer imaging?

R Chakravarty, S Chakraborty - Applied Radiation and Isotopes, 2021 - Elsevier
Over the last several years, positron emission tomography (PET) has matured as an
indispensable component of cancer diagnostics. Owing to the large variability observed …

Production cross sections of natZn(α,x)68,69Ge,66,67Ga,65Zn reactions up to 46.3 MeV

SW Raja, R Acharya, SD Chaudhuri - The European Physical Journal A, 2022 - Springer
Three medicinally important radioisotopes of Ga, 66, 67, 68Ga, having half-lives ranging
from minutes to days, could be produced from natZn (α, x) reactions. They have different …

Simple, Immediate and Calibration-Free Cyclotron Proton Beam Energy Determination Using Commercial Targets

SJC do Carmo, PM de Oliveira, F Alves - Instruments, 2019 - mdpi.com
This work presents a simple method for determining the energy of the proton beam in
biomedical cyclotrons, using no additional experimental set-up and only materials from …