Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Insulin is a major endocrine hormone also involved in the regulation of energy and lipid
metabolism via the activation of an intracellular signaling cascade involving the insulin …

Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …

The pathogenesis and etiology of diabetes mellitus (DM) and Alzheimer's disease (AD)
share many common cellular and molecular themes. Recently, a growing body of research …

Insulin inhibits systemic nonesterified fatty acid (NEFA) flux to a greater degree than glucose
or any other metabolite. This remarkable effect is mainly due to insulin-mediated inhibition of …

Metabolic syndrome (MetS) is a cluster of risk factors for various metabolic diseases, and it is
characterized by central obesity, dyslipidemia, hypertension, and insulin resistance. The …

The core phenotype of anorexia nervosa (AN) comprises the age and stage dependent
intertwining of both its primary and secondary (ie, starvation induced) somatic and mental …

Obesity and related metabolic dysregulation are risk factors for many types of cancer. The
interactions between a developing tumor and its microenvironment are known to implicate a …

Regulation on gut microbiota and short-chain fatty acids (SCFAs) are believed to be a
pathway to suppress the development of metabolic syndrome. In this study, three …

Overweight and obesity in children and adolescents are overwhelming problems in western
countries. Adipocytes, far from being only fat deposits, are capable of endocrine functions …