New treatment options in metastatic pancreatic cancer

M Fudalej, D Kwaśniewska, P Nurzyński… - Cancers, 2023 - mdpi.com
Simple Summary The poor prognosis of pancreatic cancer (PC) is associated with several
factors, such as diagnosis at an advanced stage, early distant metastases, and remarkable …

Inhibition of the PI3K/AKT/mTOR pathway in pancreatic cancer: is it a worthwhile endeavor?

AJ Ouissam, C Hind, B Sami Aziz… - … advances in medical …, 2024 - journals.sagepub.com
Pancreatic cancer (PC) is an aggressive disease that is challenging to treat and is
associated with a high mortality rate. The most common type of PC is pancreatic ductal …

Macropinocytosis-targeted peptide-docetaxel conjugate for bystander pancreatic cancer treatment

YS Cho, H Cho, HR Kim, SJ Park, JH Yeo… - Journal of Controlled …, 2024 - Elsevier
Oncogenic Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are highly
prevalent in pancreatic ductal adenocarcinoma (PDAC) and have garnered attention as …

Advancements in Preclinical Models of Pancreatic Cancer

P Salu, KM Reindl - Pancreas, 2024 - journals.lww.com
Pancreatic cancer remains one of the deadliest of all cancer types with a 5-year overall
survival rate of just 12%. Preclinical models available for understanding the disease …

[HTML][HTML] Clinical diagnosis and management of pancreatic cancer: Markers, molecular mechanisms, and treatment options

CY Zhang, S Liu, M Yang - World journal of gastroenterology, 2022 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) is the third-leading cause of cancer deaths. The overall 5-year
survival rate of PC is 9%, and this rate for metastatic PC is below 3%. However, the PC …

New Approaches in Early-Stage NSCL Management: Potential Use of PARP Inhibitors and Immunotherapy Combination

MP Fernandes, C Oliveira, H Sousa… - International Journal of …, 2023 - mdpi.com
Lung cancer is the second most common cancer in the world, being the first cause of cancer-
related mortality. Surgery remains the only potentially curative treatment for Non-Small Cell …

Development and Characterization of Olaparib-Loaded Solid Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) for Pharmaceutical Applications

Y Shin, M Kim, C Kim, H Jeon, J Koo, J Oh, S Shin… - AAPS …, 2024 - Springer
This study aims to enhance the solubility of Olaparib, classified as biopharmaceutical
classification system (BCS) class IV due to its low solubility and bioavailability using a solid …

Design, Synthesis, Docking Studies and Molecular Dynamics Simulation of New 1, 3, 5‐Triazine Derivatives as Anticancer Agents Selectively Targeting Pancreatic …

S Asghar, S Hameed, NA Al‐Masoudi… - Chemistry & …, 2024 - Wiley Online Library
On the basis of remarkable anticancer profile of s‐triazine nucleus, a new series of 2‐
methoxy‐4‐(3‐morpholino‐5‐(arylamino) phenoxy) benzaldehyde derivatives 11 a–u was …

ADP-ribosylation of telomeres in human cells

AR Wondisford - 2024 - d-scholarship.pitt.edu
The recognition that DNA can be ADP-ribosylated has major consequences for our
understanding of how ADP-ribosylation (ADPr) contributes to genome stability, epigenetics …

[图书][B] Using toxin-producing bacteria to treat explants and autochthonous mouse models of pancreatic cancer

AR Decker - 2023 - search.proquest.com
Pancreatic cancer is the 10 th most common cancer diagnosis and 4 th most common cause
of cancer mortality in the United States, highlighting a disparity between disease prevalence …