Biophysical signaling, an integral regulator of long-term cell behavior in both excitable and
non-excitable cell types, offers enormous potential for modulation of important cell functions …

Cellular therapy for cardiovascular disease heralds an exciting frontier of research.
Mesenchymal stromal cells (MSCs) are present in adult tissues, including bone marrow and …

Regenerative biology has focused largely on chemical factors and transcriptional networks.
However, endogenous ion flows serve as key epigenetic regulators of cell behavior …

Achieving control over cell behavior and pattern formation requires molecular-level
understanding of regulatory mechanisms. Alongside transcriptional networks and …

Cardiac fibrosis occurs naturally after myocardial infarction. While the initially formed fibrotic
tissue prevents the infarcted heart tissue from rupture, the progression of cardiac fibrosis …

Background and Objectives Mesenchymal stem/progenitor cells (MSCs) are multipotent
progenitors that differentiate into such lineages as bone, fat, cartilage and stromal cells that …

We have successfully developed both spontaneous and inductive cardiomyocyte
differentiation of iPS cells reprogrammed from human foreskin fibroblasts. The …

Cell-matrix interactions are paramount for the successful repair and regeneration of
damaged and diseased tissue. Since many tissues have an anisotropic architecture, it has …

The primary cause of death among chronic diseases worldwide is ischemic cardiovascular
diseases, such as stroke and myocardial infarction. Recent evidence indicates that adult …

Mesenchymal stem cells (MSCs) experience an extremely low rate of cardiac differentiation
after transplantation into infarcted hearts, in part due to the inability of stiff scar tissue to …