Tourette Syndrome (TS) is a neuropsychiatric disorder thought to involve a reduction of
basal ganglia (BG) interneurons and malfunctioning of the BG circuitry. However, whether …

The intercalated cells (ITCs) of the amygdala have been shown to be critical regulatory
components of amygdalar circuits, which control appropriate fear responses. Despite this …

Specification of dorsoventral regional identity in progenitors of the developing telencephalon
is a first pivotal step in the development of the cerebral cortex and basal ganglia. Previously …

How homeodomain proteins gain sufficient specificity to control different cell fates has been
a long-standing problem in developmental biology. The conserved Gsx homeodomain …

Emerging studies are providing compelling evidence that the pathogenesis of Huntington's
disease (HD), a neurodegenerative disorder with frequent midlife onset, encompasses …

The balance between cell proliferation and differentiation is essential for maintaining the
neural progenitor pool and brain development. Although the mechanisms underlying cell …

Neural stem cells directly or indirectly generate all neurons and macroglial cells and guide
migrating neurons by using a palisade-like scaffold made of their radial fibers. Here, we …

The Gsx2 homeodomain transcription factor promotes neural progenitor identity in the lateral
ganglionic eminence (LGE), despite upregulating the neurogenic factor Ascl1. How this …

Background Olfactory bulb (OB) interneurons are known to represent diverse neuronal
subtypes, which are thought to originate from a number of telencephalic regions including …

The striatum is the major component of the basal ganglia and is well known to play a key
role in the control of motor function via balanced output from the indirect (iSPNs) and direct …