Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Marine phycotoxins are a multiplicity of bioactive compounds which are produced by
microalgae and bioaccumulate in the marine food web. Phycotoxins affect the ecosystem …

Ionotropic glutamate receptors (iGluRs) are a major class of ligand‐gated ion channels that
are widespread in the living kingdom. Their critical role in excitatory neurotransmission and …

Since the 1990s, ionotropic glutamate receptors have served as an outstanding target for
drug discovery research aimed at the discovery of new neurotherapeutic agents. With the …

Background: A dysfunction in glutamate neurotransmission is critical for seizure. Glutamate
is the major excitatory drive in the cerebral cortex, where seizures occur. Glutamate acts via …

Glutamate receptor-like channels (GLRs) play important roles in numerous plant
physiological processes. GLRs are homologous to ionotropic glutamate receptors (iGluRs) …

Kainate receptors (KARs) are L-glutamate-gated ion channels that regulate synaptic
transmission and modulate neuronal circuits. KARs have strict assembly rules and primarily …

Hypoxic-ischemic encephalopathy (HIE) is one of the leading pediatric neurological
conditions causing long-term disabilities and socio-economical burdens. Nearly 20-50% of …

Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in
regulating neuronal excitability and network function in the brain. After being cloned in the …

Neural communication and modulation are complex processes. Ionotropic glutamate
receptors (iGluRs) significantly contribute to mediating the fast-excitatory branch of …